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Topic: Receptor Biology and Signal Transduction
Session Type: Symposium

SY34 - Pioneering Metabolism: The Mangelsdorf Legacy and Beyond

Sunday, June 14, 2026
4:30 PM - 6:00 PM CT
Location: Room W183A

    Symposium Chair(s)

  • Carolyn Cummins, PhD (she/her/hers)

    Associate Professor
    Leslie Dan Faculty of Pharmacy
    University of Toronto
    Toronto, ON, Canada

    Disclosure(s): No financial relationships to disclose

  • Phillip Dumesic, MD, PhD

    Assistant Professor
    University of California, San Francisco
    San Francisco, CA, United States

    Disclosure(s): No financial relationships to disclose

Disclosure(s):
Carolyn L. Cummins, PhD: No financial relationships to disclose
Phillip Dumesic, MD, PhD: No financial relationships to disclose
Ines Pineda Torra, PhD: No financial relationships to disclose

This session will focus on advances in nuclear receptor biology and metabolic regulation inspired by the Mangelsdorf legacy. The session celebrates landmark discoveries that continue to reshape our understanding of metabolic regulation across tissues and disease states. We will explore how nuclear receptors, bile acids, and endocrine factors integrate intestinal, hepatic, and central nervous system signaling to control lipid handling, fasting responses, and metabolic disease. Talks will span intestinal cholesterol sensing via LXR, FGF21-mediated reversal of liver disease through CNS-liver crosstalk, bile acid-ER interactions, and the transcriptional control of PPARĪ± during fasting. Together, these presentations highlight the enduring impact of Mangelsdorf's legacy while pointing to new therapeutic opportunities for cardiometabolic and liver disease.

Presentations:

  • 4:30 PM - 4:54 PM CT
    Interplay Between Bile Acids and ER Actions

    Symposium Speaker: Sayeepriyadarshini Anakk, PhD – University of Illinois

  • 4:54 PM - 5:16 PM CT
    Partitioning Fasting Fuel Programs: PPARĪ± Drives Ketogenic Gene and Enhancer Activation Without Directly Regulating Gluconeogenesis

    Symposium Speaker: Ido Goldstein, Ph.D. (he/him/his) – THE HEBREW UNIVERSITY OF JERUSALEM

  • 5:16 PM - 5:38 PM CT
    Nuclear receptor FXR and the enterokine FGF19 in the gut-liver axis

    Symposium Speaker: Antonio MOSCHETTA – University of Bari "Aldo Moro" - Policlinico

  • 5:38 PM - 6:00 PM CT
    FGF21: Stopping the Monster MASH

    Symposium Speaker: Matthew Potthoff, PhD – THE UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER