SY66 - Hardwired: Where Nerves Meet Bones

Symposium Chair(s)

• 

  Muriel Babey, MD (she/her/hers)

  Assistant Professor of Medicine
  Stanford University, Division of Endocrinology, Gerontoloy and Metabolism
  Kensington, CA, United States

  Disclosure(s): No financial relationships to disclose
• 

  Rajesh Jain, MD

  Department of Medicine, Section of Endocrinology
  UNIVERSITY OF CHICAGO
  Chicago, IL, United States

  Disclosure(s): Amolyt Pharma: Clinical Trial Investigator (); Ascendis Pharma: Clinical Trial Investigator (); Guidepoint: Consultant (); Iambic: Consultant (); MBX: Clinical Trial Investigator ()

This session will explore how neurologic and neuromuscular conditions influence bone health through three interconnected themes. First, attendees will examine emerging evidence on how neural pathways regulate bone formation, including how disruptions in sensory‑neuron signaling can trigger heterotopic ossification following injury or in rare genetic conditions. The session will then discuss the skeletal consequences of stroke and prolonged disuse, highlighting how loss of mechanical loading leads to rapid reductions in bone density and structural integrity. Finally, the program will address the profound impact of neuromuscular disorders-such as Duchenne muscular dystrophy-on bone fragility, focusing on the combined roles of muscle weakness, reduced mobility, and long‑term glucocorticoid use in elevating fracture risk. Together, these discussions will provide an integrated understanding of how nervous system injury, immobility, and muscle disease converge to shape long‑term.

Presentations:

• 9:00 AM - 9:30 AM CT

  Race and Ethnicity in Osteoporosis: Time to Reconsider
  

  Symposium Speaker: Rajesh K. Jain, MD – UNIVERSITY OF CHICAGO
• 9:30 AM - 10:00 AM CT

  Skeletal Fragility in Duchenne Muscular Dystrophy: Closing the Gap Between Risk and Intervention
  

  Symposium Speaker: Leanne M. Ward, MD, FRCPC – Children's Hospital of Eastern Ontario, University of Ottawa
• 10:00 AM - 10:30 AM CT

  Novel Insights into Neurologic Control of Osteogenesis
  

  Symposium Speaker: Xiaobing Yu, MD (he/him/his) – University of California, San Francisco