Topic: Diabetes and Vascular Disease

SY70 - Out of Breath: Where Insulin Resistance Impacts Cardiorespiratory Fitness

Symposium Chair(s)

• 

  Zhenqi Liu, MD

  Professor of Medicine
  University of Virginia
  Charlottesville, VA, United States

  Disclosure(s): No financial relationships to disclose
• 

  Nathan Winn, PhD (he/him/his)

  VANDERBILT UNIVERSITY MEDICAL CENTER
  Nashville, TN, United States

  Disclosure(s): No financial relationships to disclose

This session will explore the intersection of insulin resistance and cardiorespiratory fitness (CRF), two key predictors of metabolic disease and mortality. Speakers will examine mechanistic, clinical, and translational insights into mitochondrial function, muscle insulin signaling, and aerobic capacity. The session will also address the impact of exercise and medications (e.g. metformin and GLP-1RAs), emphasizing the importance of targeting both insulin sensitivity and CRF to improve metabolic health.


Learning Objectives

Describe the mechanistic links between mitochondrial function, skeletal muscle insulin signaling, and cardiorespiratory fitness.

Evaluate the impact of exercise and pharmacologic interventions, including GLP-1 receptor agonists, on insulin resistance and aerobic capacity.

Identify clinical and research strategies that simultaneously target insulin sensitivity and cardiorespiratory fitness to reduce metabolic disease risk.

Presentations:

• 10:45 AM - 11:15 AM CT

  Metformin Impairment of Vascular Insulin Sensitivity After Exercise
  

  Symposium Speaker: Steven Malin, PhD (he/him/his) – Rutgers University
• 11:15 AM - 11:45 AM CT

  Vascular Insulin Resistance and Cardiorespiratory Fitness
  

  Symposium Speaker: Jane E. Reusch, MD – University of Colorado Anschutz Medical Campus
• 11:45 AM - 12:15 PM CT

  Reclassifying Type 2 Diabetes Through Immune System Architecture
  

  Symposium Speaker: Nicolas Venteclef – Necker Institute