David R. Zak, B.S. (he/him/his)

LOYOLA UNIVERSITY OF CHICAGO
Oak Park, IL, United States

David Zak, PhD candidate in the Sean Fanning Lab. Department of Biochemistry, Molecular and Cancer Biology, at Loyola University Chicago. My research focuses on ligand specific conformation dynamics and protein-protein interactions of Estrogen Receptor Alpha in estrogen responsive tissues following treatment with clinically relevant endocrine therapies. Our goal is to elucidate the mechanism of SERM/D tissue specific action by bridging the gap between static x-ray co-crystal structures and transcriptome, by through structural mass-spectrometry, MDsim, and proteomics.

Disclosure information not submitted.

Presentation(s):

• SAT-289 - Development of Thienopyrimidine-Based Selective Estrogen Receptor Degraders for Breast Cancer

  Saturday, June 13, 2026
  9:30 AM - 4:30 PM CT

• ORF11-04 - Ligand Specific Estrogen Receptor Conformational Dynamics

  Saturday, June 13, 2026
  2:00 PM - 2:15 PM CT

• ORF48-05 - Ligand and Context Specific Estrogen Receptor Interactomes

  Monday, June 15, 2026
  2:15 PM - 2:30 PM CT