Full Member/Professor
St. Jude Children's Research Hospital
Memphis, TN, United States
Dr. Taosheng Chen is a Professor (Full Member) of Chemical Biology & Therapeutics Department, and Director of High Throughput Bioscience Center at St. Jude Children’s Research Hospital, USA. He received his BS and MS from Fudan University, Ph.D. from University of Vermont and completed postdoctoral training at University of Virginia. Prior to joining St. Jude in 2006, he was a Senior Research Investigator at Bristol-Myers Squibb, and a Research Scientist at SAIC-Frederick, National Cancer Institute. He serves on several journal Editorial Boards, and NIH grant review panels and study section (e.g., chairperson of the DMP study section). He has authored more than 200 publications (in journals such as Nat Commun, PNAS, JACS, including 2 books), and 19 patents. His laboratory studies the regulation of nuclear receptors PXR and CAR and drug-metabolizing enzymes CYP3A4 and CYP3A5, by using biology, chemistry and structural biology approaches to develop novel chemical probes for mechanistic studies and lead compounds for therapeutic development. The goals are to understand nuclear receptor-regulated transcription networks, enzyme-drug interactions, and design therapeutic approaches to overcome drug resistance and toxicity - the leading causes of therapeutic failures.
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SY53-02 - Nuclear Receptor Degradation Mechanisms: PXR as a Case Study
Monday, June 15, 2026
5:00 PM - 5:30 PM CT