Bone and Mineral Metabolism

SUN-829 - Anthropometric Indices and Markers of Atherothrombotic Risk in Subjects with Primary Hyperpathyroidism.

Sunday, June 14, 2026

9:00 AM - 4:00 PM CT

Location: ENDOExpo; Poster Floor

Abstract Poster Presenter(s)

ES

Eleonora Sargentini, MD

Fondazione Policlinico Universitario Campus Bio-Medico of Rome
Rome, Italy

Co-Author(s)

MB

Marco Bravi, PhD

Fondazione Policlinico Universitario Campus Bio-Medico of Rome
Rome, Italy
AN

Annunziata Nusca, MD

Campus Bio-Medico University of Rome
Rome, Italy
FG

Francesco Grigioni, MD, PhD

Campus Bio-Medico University of Rome
Rome, Italy
LB

Luigi Bonifazi Meffe, MD

Fondazione Policlinico Universitario Campus Bio-Medico of Rome
Rome, Italy
NN

Nicola Napoli, MD, PhD

Fondazione Policlinico Universitario Campus Bio-Medico of Rome
Rome, Italy
GT

Gaia Tabacco, MD, PhD

Fondazione Policlinico Universitario Campus Bio-Medico of Rome
Rome, Italy
AP

Andrea Palermo, MD (he/him/his)

Professor
Fondazione Policlinico Universitario Campus Bio-Medico
Rome, Italy

Senior Author/Primary Investigator(s)

AN

Anda Mihaela Naciu, MD, PhD

Fondazione Policlinico Universitario Campus Bio-Medico of Rome
Rome, Italy

Background: Both primary hyperparathyroidism (PHPT) and chronic hypoparathyroidism (HypoPT) are associated with the onset and development of cardiovascular diseases (CVDs). Especially PHPT is accompanied by the presence of elevated atherothrombotic risk, while the importance of traditional and new anthropometric indices to reflect the cardiovascular risk remains uncertain in this condition. This study aims to investigate whether novel and traditional anthropometric indices distinguish PHPT and their correlation with atherothrombotic risk.

Methods: 40 Subjects with HypoPT, 40 PHPT and 40 age- and sex-matched control subjects were consecutively enrolled for the evaluation of flow-mediated vasodilation (FMD) and carotid intimal-media thickness (IMT). A blood sample was collected for calcium-phosphate metabolism, PTH, TSH and 25-hydroxy vitamin D evaluation. Physical examination was performed to obtain traditional anthropometric parameters and derived indices of adiposity and cardiometabolic risk (waist height ratio (WHtR) and waist hip ratio (WHR) and conicity index (CI)).

Results: The PHPT group showed higher central adiposity indices (WHtR p=0.002, and CI p=0.008). Among patients with parathyroid disorders, PHPT subjects display the highest reduction of FMD (p < 0.001) and a marked increase of IMT (p < 0.001). In the Ctrl group, WHtR showed a weak-to-moderate positive association with IMT (r=0.381, p=0.018). In the PHPT group, no anthropometric index was significantly correlated with IMT or FMD (all p>0.05).

Conclusions: WHtR and CI provide evidence of increased central fat adiposity in PHPT but do not account for impaired atherothrombotic risk, indicating that anthropometric indices may lack relevance to cardiovascular risk in this condition and emphasising the importance of a specific assessment profile.

*Unless otherwise noted, all abstracts presented at ENDO must not be released to the press or the public until the date and time of presentation. For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO.*