Indroduction: Adolescents with idiopathic short stature (ISS) pose a therapeutic challenge due to the decreased efficacy of growth hormone (GH) treatment, attributed to accelerated skeletal maturation induced by sex steroids and premature fusion of growth plate leading to final short stature.
Methods: Adolescent males were included with bone age between 12-14 years without genetic or hormonal alteration, Letrozol 2.5 mg and Growth Hormone 0.04 mg / kg / day were started. Patients were evaluated every 3 months till final height defined as bone age 15 years or growth velocity below 1 cm during 6 months. Adult final height was calculated using the Bayley-Pinneau method. Data is expressed as mean ± standard deviation (M ± SD).
Results: 31 male adolescents were included. Initial age was 11.8 years ± 1.3; Initial height was 146.2 cm ± 7.6 with an initial bone age of 12.6 ± 1.1 . Projected Adult height was 162.8 cm ± 3.4 and final height was 168.2 cm ± 3.1 , with a total increase of 5.4 cm in final height . Duration of therapy was 2.8 ± 0.4 years No side effects were observed during the therapy.
Conclusion: In adolescent males with ISS and bone age over 12 years, combined therapy with growth hormone and Letrozol significantly improves adult height with no side effects observed during the therapy.
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