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Pediatric and Adolescent Endocrinology

SAT-201 - Degree of Glycemic Control and Variability in Hispanic Adolescents with and without Polycystic Ovary Syndrome: A Preliminary Analysis

Saturday, June 13, 2026
9:30 AM - 4:30 PM CT
Location: ENDOExpo; Poster Floor
Disclosure(s):
Heidi Vanden Brink, PhD MSc: National Cattlemen's Beef Association: Grant Recipient ()


Objective: Polycystic ovary syndrome (PCOS) in adolescence increases the risk for Type 2 Diabetes, which is disproportionately greater among Hispanic adolescents. However, existing evidence is largely derived from medical chart reviews; degree of progressive dysglycemia among adolescents with suspected PCOS, particularly among underrepresented groups, is unclear. We present a preliminary analysis of an ongoing study to: i) assess whether Hispanic adolescents with suspected PCOS exhibit worse glucose metrics assessed via blinded Continuous Glucose Monitors (CGMs); and ii) determine whether degree of CGM-defined glycemic measures are associated with endocrine features of PCOS.

Methods: Hispanic adolescent females from South Texas with none or one diagnostic feature of PCOS (No PCOS, n=9) and who met criteria for PCOS (n=7) were invited to wear a blinded CGM for 14 days. Time in Range (TIR; 70-180 mg/dL); Time in Tight Range (TITR, 70-140 mg/dL), Time in Ultra Tight Range (TIUTR, 80-120 mg/dL), and Time in Hypoglycemia (Level 1; 54-70 mg/dL; Level 2; < 54 mg/dL), mean glucose and standard deviation (SD), coefficient of variation (CV), and Glucose Management Indicator (GMI) were computed from blinded wear. Groups were compared using Wilcoxon rank-sum analyses. Spearman’s correlation coefficients were calculated to assess bivariate correlations between measures of glucose ranges and variability with metabolic and reproductive outcomes. Significance was defined as p < 0.05.

Results: CGM-derived metrics did not differ by PCOS status (p = 0.05). LH:FSH ratio was positively associated with the percentage of time spent in Level 1 Hypoglycemia (rho = 0.512, p = 0.0427) and AMH was inversely associated with overall SD (rho = -0.592, p = 0.0159). BMI was inversely correlated with overall mean glucose and the GMI score (rho = -0.553, p = 0.0263; rho = -0.566, p = 0.022).

Conclusion: Degree of reproductive dysfunction and adiposity in Hispanic adolescents may be associated with CGM-derived times in glucose ranges and glycemic variability. Research is ongoing to corroborate these findings in a larger sample size.

*Unless otherwise noted, all abstracts presented at ENDO must not be released to the press or the public until the date and time of presentation. For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO.*