SUN-025 - Clinical and Body Composition Determinants of Quality of Life in Patients with Acromegaly

Title: Clinical and Body Composition Determinants of Quality of Life in Patients with Acromegaly

Background:
Acromegaly is a chronic endocrine disorder associated with substantial physical, metabolic, and psychosocial burden. Despite biochemical control, many patients continue to experience impaired quality of life (QoL). Identifying clinical and anthropometric factors associated with QoL may guide more comprehensive patient management.

Methods:
In this cross-sectional study, 42 patients with acromegaly followed in a tertiary endocrinology center and 45 age- and sex-matched healthy controls were evaluated. Demographic data, clinical characteristics, comorbidities, treatment history, and pituitary features were recorded. Body composition was assessed using bioimpedance analysis. Quality of life was evaluated using the disease-specific AcroQoL questionnaire and the generic SF-36 scale. Associations between clinical parameters, body composition variables, and QoL scores were analyzed.

Results:
The mean age of patients was 54.8 ± 11.5 years, and 45.2% were female. Hypertension, diabetes mellitus, cardiac disease, thyroid nodules, and pituitary insufficiency were common comorbidities. Male sex, older age, later age at diagnosis, lower body weight, lower body mass index, and lower body fat percentage were associated with higher scores in most AcroQoL domains. Smaller adenoma size at diagnosis and the absence of cardiac pathology, hypertension, thyroid nodules, and multinodular goiter were associated with better scores in selected QoL subdomains. Prior radiotherapy was also related to higher scores in specific domains. Compared with controls, patients exhibited significantly impaired QoL in several SF-36 dimensions.

Conclusion:
Quality of life in acromegaly is influenced not only by disease-related factors but also by body composition and comorbidity burden. Lower adiposity and fewer systemic complications are associated with better patient-reported outcomes. Multidisciplinary management, early diagnosis, and routine monitoring of body composition may help optimize long-term quality of life in acromegaly.
Keywords: acromegaly, quality of life, AcroQoL, body composition, bioimpedance

*Unless otherwise noted, all abstracts presented at ENDO must not be released to the press or the public until the date and time of presentation. For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO.*