SAT-411 - Evaluation of Serum Prolidase Levels and Inflammation Markers in Patients with Non-Functional Adrenal Incidentalomas

Adrenal incidentalomas refer to adrenal masses detected during routine imaging studies in individuals who have no symptoms or physical findings related to the adrenal gland. Matrix metalloproteinases (MMPs) have important functions in collagen metabolism and extracellular matrix remodelling. Activation of MMPs leads to the degradation of the extracellular matrix. Prolidase, a member of the MMP family, acts by cleaving proline and hydroxyproline.
In this study, we aimed to evaluate serum prolidase levels in patients with adrenal incidentalomas which were shown to be nonfunctional and to investigate the relationship between prolidase levels and anthropometric measurements, inflammation markers, dexametasone supressed cortisol (DSC) levels and the radiological characteristics of the adenomas.
Ninety six patients with nonfunctional adrenal incidentalomas(NFAI) and 48 healthy individuals were included and an observational study was conducted. Weight, height, neck and hip circumference were measured and neutrophil/ lymphocyte ratio, C reactive protein (CRP), erithrocyte sedimentation rate(ESR) and fibrinogen levels were obtained. Cortisol levels measured after an overnight dexametasone were recorded.
Of our patients 74% were women, the average age of diagnosis was 55 years and 66.6 % were obese. The most common concomittant diseases were obesity, hypertension and diabates mellitus in order of frequency. The patients were admitted most often as a result of gastrointestinal complaints and were diagnosed most often on imaging performed by computed tomography. The average mass size was 21.29mm. There was no significant difference in serum prolidase levels between the patients and the healthy group. There was a negative correlation between serum prolidase and DSC levels (p:0.011). Also there was a positive correlation between adenoma size and DSC levels (p:0.021). The mean fibrinogen levels were high in patients. A positive relationship was detected between body masss index(BMI) and neutrophil/lymphocyte ratio, CRP, ESR and adenoma size.
These findings suggest that in patients with higher DSC levels collagen breakdown might be impaired and adenoma mass size contributes to higher cortisol secretion. Also there is some clue to suggest that higher BMI might be operative in adrenal adenoma development. This research contributes to the literature by examining the prolidase enzyme in patients with NFAI.

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