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Cardiovascular Endocrinology

SAT-270 - Validation of Friedewald, Martin, and Sampson Equations for Estimating LDL Cholesterol in a Pediatric Population

Saturday, June 13, 2026
9:30 AM - 4:30 PM CT


Background: In 2013, the Martin equation was proposed to estimate low-density lipoprotein cholesterol (LDL-C) with greater accuracy than traditional methods. Its application is particularly relevant for monitoring LDL-C levels in Mexican schoolchildren and adolescents, given the increasing prevalence of childhood obesity and the early risk of cardiovascular disease. Therefore, the aim of this study was to validate the Martin equation for estimating LDL-C in Mexican pediatric patients.

Methods: Pediatric participants aged 2 to 17 years were included. A lipid profile was measured, including LDL-C, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG), with all parameters expressed in mg/dL. Participants who did not meet the fasting requirement or who had consumed vitamin C or paracetamol were excluded. Blood samples were collected after an 8--10 hour fasting period. Total cholesterol, triglycerides, HDL-C, and LDL-C were measured in serum using an enzymatic colorimetric method. LDL-C levels were estimated using the Martin equation. Statistical analysis was performed using the intraclass correlation coefficient (ICC) to assess agreement between LDL-C estimated by the Martin equation and LDL-C measured by the laboratory reference method.

Results: The equation was applied to 400 participants. Agreement between the Martin equation and the reference LDL-C measurement was 0.948 (95\% CI: 0.937--0.957).

Conclusions: Excellent agreement was observed between LDL-C estimated by the Martin equation and laboratory measurements, supporting its use for LDL-C estimation in clinical practice.

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