Skip to main content
ENDO 2026 Main banner

Adipose Tissue_Appetite_and Obesity

MON-677 - Adipose-Specific Deletion of Alternative BA Synthesis Regulates Basal Metabolic Rate and Insulin Metabolism

Monday, June 15, 2026
9:00 AM - 2:00 PM CT
Location: ENDOExpo; Poster Floor
Disclosure(s):
Sayeepriyadarshini Anakk, Ph.D.: No financial relationships to disclose
Weinan Zhou, PhD: No financial relationships to disclose
Cytochrome P450 27-hydroxylase (CYP27A1) has been widely studied as one of the enzymes responsible for alternative bile acid (BA) synthesis. Recently, BAs have been detected in the adipose depots, and they have been used to reduce the lipid droplet size and shown to promote fat burning. However, little is known about the function of CYP27A1 in the adipose tissue. Unpublished data from our group have shown that, after differentiation of isolated preadipocytes from murine white adipose tissue (WAT), Cyp27a1 expression is approximately 20-fold higher than that of Cyp7a1, the rate-limiting enzyme of the classical bile acid synthesis pathway. A global Cyp27a1 KO model showed lower BA concentration in WAT and limited differentiation ability in WAT preadipocytes compared to wild-type (WT) mice. We also generated adipose-specific Cyp27a1 knockout mice using floxed Cyp27a1 and Adiponectin Cre. Our pilot findings show that loss of Cyp27a1 gene improves glucose and insulin tolerance, as well as energy expenditure, indicating a novel role for this pathway in the adipose milieu.

*Unless otherwise noted, all abstracts presented at ENDO must not be released to the press or the public until the date and time of presentation. For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO.*