ORF49 - See Through TED

ORF Chair-Primary(s)

• 

  Debbie Chen, MD (she/her/hers)

  Clinical Assistant Professor
  University of Michigan
  Ann Arbor, MI, United States

  Disclosure information not submitted.

From basic discoveries to results of clinical trials, this session highlights advances in thyroid eye disease and Graves'

Presentations:

• 1:45 PM - 1:50 PM CT

  RARRES1 Is Highly Expressed in Thyroid Eye Disease Orbital Fibroblasts and Regulates IL-17 -Dependent MCP-1 Production
  

  Submitting author: Phillip Van Truong, M.S. (he/him/his) – UNIVERSITY OF ROCHESTER SCHL OF MED/DENTISTRY

  Rapid and Poster Presenter: Phillip Van Truong, M.S. (he/him/his) – UNIVERSITY OF ROCHESTER SCHL OF MED/DENTISTRY

  Co-Author: Elisa Roztocil, n/a – Department of Ophthalmology, University of Rochester

  Senior Author/Primary Investigator: Collynn F. Woeller, PhD – University of Rochester

  Co-Author: Steven Feldon, MD – Department of Ophthalmology, University of Rochester
• 1:50 PM - 1:55 PM CT

  Hydrogen Sulfide Is Reduced in Graves' Disease and May Attenuate Autoantibody Secretion
  

  Submitting author: Shengya Xu, MD (they/them/theirs) – PEKING UNIVERSITY FIRST HOSPITAL

  Rapid and Poster Presenter: Shengya Xu, MD (they/them/theirs) – PEKING UNIVERSITY FIRST HOSPITAL

  Co-Author: Liming Wang, Dr. – Department of Endocrinology, Peking University First Hospital

  Co-Author: Xinyu Li, Dr. – Department of Endocrinology, Peking University First Hospital

  Co-Author: Youyuan Huang, Dr. – Department of Endocrinology, Peking University First Hospital

  Co-Author: Boyang Lyv, Dr. – Department of Pediatrics, Children's Medical Center, Peking University First Hospital

  Co-Author: Hongfang Jin, Dr. – Department of Pediatrics, Children's Medical Center, Peking University First Hospital

  Senior Author/Primary Investigator: Yedi Cao, Dr. (she/her/hers)

  Senior Author/Primary Investigator: Ying Gao, Prof. – Department of Endocrinology, Peking University First Hospital

  Rapid and Poster Presenter: Yang Zhang (she/her/hers) – Peking University First Hospital
• 1:55 PM - 2:00 PM CT

  Thyroid Eye Disease Following Immunomodulatory Therapy for Multiple Sclerosis: A Case Series
  

  Submitting author: Sandhi Wynn Nyunt, MBBS MPH MRCP (she/her/hers) – Imperial College London

  Rapid and Poster Presenter: Sandhi Wynn Nyunt, MBBS MPH MRCP (she/her/hers) – Imperial College London

  Co-Author: Mohammud Musleh, n/a – Imperial College Healthcare NHS trust

  Co-Author: Claire Feeney, n/a – Imperial College NHS Healthcare Trust

  Co-Author: Ahmad Aziz, n/a – Imperial College Healthcare NHS trust

  Co-Author: Vassiliki Bravis, n/a – IMPERIAL COLLEGE SCHOOL OF MEDICINE

  Co-Author: Richard Nicholas, n/a – Imperial College Healthcare NHS Trust

  Co-Author: Karim Meeran, n/a – Imperial College London

  Co-Author: Vickie Lee, n/a – Imperial College Healthcare NHS Trust
• 2:00 PM - 2:15 PM CT

  Characterization of Proptosis Response in the THRIVE Phase 3 Trial of Veligrotug for Active Thyroid Eye Disease (TED)
  

  Oral Abstract Presenter: Madhura Tamhankar, MD – Scheie Eye Institute, University of Pennsylvania

  Co-Author: Steven Leibowitz, MD – UCLA Stein Eye Institute

  Co-Author: Raghu Mudumbai, MD – University of Washington Medical Center

  Co-Author: Kimberly Cockerham, MD – Brady Neuroscience Clinic

  Co-Author: Jody Abrams, MD – Sarasota Retina Institute

  Co-Author: Roger Turbin, MD – RUTGERS STATE UNIVERSITY

  Co-Author: Navdeep Nijhawan, MD – University of Toronto

  Co-Author: Sandy Zhang-Nunes, MD – USC Roski Eye Institute

  Co-Author: Andrea Kossler, MD – Stanford University

  Co-Author: Ashley Pajak, MS – Viridian Therapeutics, Inc.

  Co-Author: Abhijit Narvekar, MS – Viridian Therapeutics, Inc.

  Co-Author: Michael Yen, MD – BAYLOR COLLEGE OF MEDICINE
• 2:15 PM - 2:30 PM CT

  Results from a Phase 1b Trial Evaluating CD40-Ligand Blocker Lu AG22515 in Patients with Moderate-to-Severe Thyroid Eye Disease
  

  Oral Abstract Presenter: Agneta Snoer, MD, PhD (she/her/hers) – H LUNDBECK A/S

  Co-Author: Agneta Snoer, MD, PhD (she/her/hers) – H LUNDBECK A/S

  Co-Author: Jordi Clarimon, PhD – H. Lundbeck A/S, Valby, Denmark

  Co-Author: Aksel Rasmussen, PhD – H. Lundbeck A/S, Valby, Denmark

  Co-Author: Lene Hansen, PhD – H. Lundbeck A/S, Valby, Denmark

  Co-Author: Hanne Garling, PhD – H. Lundbeck A/S, Valby, Denmark

  Co-Author: Terry J. Smith, MD – Department of Ophthalmology and Visual Sciences and Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA

  Co-Author: Miloš Žarković, Professor. MD, PhD – University of Belgrade

  Co-Author: Tina Overgaard, PhD – H. Lundbeck A/S, Valby, Denmark
• 2:30 PM - 2:45 PM CT

  New Insights into the Graves' Disease Reactome - Characterization of Hinge Region TSH Receptor Antibodies in the Serum of Patients with Graves' Disease
  

  Submitting author: Pingping Xiang, MD, PHD (she/her/hers) – Ichan school of Medicine at Mount Sinai

  Oral Abstract Presenter: Pingping Xiang, MD, PHD (she/her/hers) – Ichan school of Medicine at Mount Sinai

  Co-Author: Se-Min Kim, MD (he/him/his) – Institute for Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

  Co-Author: Rauf Latif, PhD – Institute for Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

  Senior Author/Primary Investigator: Terry Davies, MD – Institute for Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
• 2:45 PM - 3:00 PM CT

  ETHY-001, a Half-Life Extended, TSHR Monoclonal Antibody Antagonist, Potently Inhibits TSHR Activation Induced by Patient Sera and M22-Induced Hyaluronan and IL-6 Secretion from TED Patient-Derived Orbital Fibroblasts
  

  Co-Author: Lauren Pepper, PhD – Ethyreal Bio

  Co-Author: Phillip V. Truong, M.S. (he/him/his) – UNIVERSITY OF ROCHESTER SCHL OF MED/DENTISTRY

  Co-Author: Elisa Roztocil, n/a – University of Rochester

  Co-Author: Gina-Eva Gortz, PhD – University Hospital Essen

  Co-Author: Mareike Horstmann, B.Sc. – University Hospital Essen

  Co-Author: Jasvinder Paul Banga, n/a (he/him/his) – King's College London

  Co-Author: Collynn F. Woeller, PhD – University of Rochester

  Co-Author: Anja Eckstein, n/a – University Hospital Essen

  Co-Author: Stephen A. Huang, MD – Ethyreal Bio

  Submitting author: Kelly Foster, PhD – Ethyreal Bio

  Oral Abstract Presenter: Kelly Foster, PhD – Ethyreal Bio
• 3:00 PM - 3:15 PM CT

  Subcutaneous MHB018A, a N Ovel Anti- IGF-1R VHH Antibody, for Thyroid Eye Disease (TED): Results from a Phase 1/2 Study in Patients with Active and Chronic TED
  

  Senior Author/Primary Investigator: Zibing Jin, MD, PhD – Beijing Tongren Hospital

  Co-Author: Jianbo Zhou, MD, PhD – Beijing Tongren Hospital

  Co-Author: Yuhong Shi, MD, PhD – The 2nd Affiliated Hospital of Chengdu Medical College Nuclear Industry 416 Hospital

  Co-Author: Xiaorong Li, MD, PhD – Tianjin Medical University Eye Hospital

  Co-Author: Hongwei Jiang, MD, PhD – The First Affiliated Hospital of Henan University of Science and Technology

  Co-Author: Yihua Wang, MD – Nanyang First People's Hospital

  Co-Author: Liming Tao, MD, PhD – The Second Affiliated Hospital of Anhui Medical University

  Co-Author: Xiaohong Wu, MD, PhD – Zhejiang Provincial People's Hospital

  Co-Author: Tao Wang, MD – The First Affiliated Hospital of Xinxiang Medical University

  Co-Author: Yu Zhu, MD, PhD – The First Affiliated Hospital of Zhengzhou University

  Co-Author: Jin Yao, MD, PhD – Nanjing Medical University Eye Hospital

  Co-Author: Ji Hu, MD, PhD – The Second Affiliated Hospital of Soochow University

  Co-Author: Yanjie Tian, MD – Peking University Third Hospital

  Co-Author: Jia Tan, MD, PhD – Xiangya Hospital of Central South University

  Co-Author: Wencheng Su, MD, PhD – Deyang People's Hospital

  Submitting author: Shiyu Zhou, PhD – Minghui Pharmaceutical

  Co-Author: Shiyu Zhou, PhD – Minghui Pharmaceutical

  Co-Author: Junwei Shi, MA – Minghui Pharmaceutical

  Oral Abstract Presenter: Guoqing Cao, PhD – Minghui Pharmaceutical