Professor University of Michigan Ann Arbor, MI, United States
Disclosure(s):
Carey Lumeng, MD PhD: Van Andel Institute: Advisory Board ()
Adipose tissue is a dynamic, heterogeneous organ that integrates metabolic, immune, and endocrine functions. This session will highlight discoveries from single-cell and multi-omic studies revealing how adipose composition changes across the lifespan and during weight loss. Speakers will discuss novel adipocyte and stromal cell subtypes, the diverse roles of macrophages and B-cells in inflammation and tissue repair, and insights from the adipose secretome that redefine fat as a central metabolic regulator. Together, these talks provide a multidimensional view of adipose biology and identify emerging therapeutic targets for obesity and metabolic disease.
Learning Objectives:
Describe how single-cell sequencing and spatial transcriptomics have advanced understanding of adipose cellular heterogeneity across age and during weight change.
Explain the regulatory roles of immune cell subsets—including macrophages and B-cells—in mediating adipose tissue inflammation, resolution, and remodeling.
Discuss how adipose tissue secreted factors (the “secretome”) integrate local and systemic metabolic signaling and identify their implications for therapeutic development.
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